The new world excellence in Life Sciences

 

Located inside Milan Innovation District MIND, Human Technopole (HT) is a large-scale, government-funded, research infrastructure that contributes to improving human health and well-being by developing new approaches to personalised and preventive medicine. 

Currently recruiting its researchers – that will be 100 at the end of 2021 - it will reach its full capacity in 2026 with >1,000 scientists recruited. Prof. Iain Mattaj is the Director of the institute since January 2019. Other internationally renowned scholars are already part of the project, Prof. Giuseppe Testa, Prof. Pietro Carninci, Prof. Nicole Soranzo, Prof. Andrea Sottoriva and Prof. Alessandro Vannini, among others.

Thanks to state-of-the-art laboratories and facilities and highly qualified scientific staff, HT is expected to be enlisted in the world’s most advanced hubs thanks to the acquisition of exclusive computing, storage and imaging equipmentGenomics studiesbig data analysis and new diagnostics techniques will be supported by unique technologies which will be made available to the wider national and international scientific community.

Research Centres

- Genomics

The Centre studies genomics characteristics and traits to identify how hereditable genetic information is shared in view of identifying more personalised treatments.

 

- Neurogenomics

The Centre studies neuropsychiatric and neurological diseases to probe the structure, function and development of the nervous system.

 

- Structural Biology

The Centre aims at gaining precise knowledge of the structure of macromolecules, a fundamental step in understanding the function of cells.

 

- Computational Biology

The Centre develops solutions for the analysis, management and integration of data produced by other Centres, making it available to the wider scientific community.

 

- Analysis decisions and Society

The Centre analyses clinical and socio-economic data to provide advice to different stakeholders, in particular policymakers, mainly to the national health system.

Cryo-electron microscopy laboratory

"Titan Krios", "Spectra", "Glacios", "Talos" e "Aquilos" are the names of the up to 3-metre tall electronic cryo-microscopes Human Technopole is equipped with.

Unique in Italy and only present in few of the most advanced scientific facilities worldwide, these sophisticated tools are used to study the functioning of genes and proteins with the aim of finding new solutions against tumors and neurodegenerative diseases.

The laboratory dedicated to cryo-electron microscopy, where the equipment is located, will be fully accessible also to other research institutions and projects for the benefit of science and human health.

Flagship Initiatives

- Moli-sani

The Genomics Centre will carry out a complete genomic characterisation of the "Moli-sani" study, carried out by the Istituto Neurologico del Mediterraneo - Neuromed IRCCS.
Moli-sani is a study aimed at assessing risk/protective factors (e.g. environmental, genetic, biomolecular) related to chronic degenerative diseases - with particular regard to cancer, cardiovascular diseases and their intermediate phenotypes including hypertension, diabetes, dyslipidemia, obesity and metabolic syndrome. Between 2005 and 2010, the study recruited more than 24,000 people aged ≥35 years in the Molise region. Participants in the Moli-sani study underwent intensive phenotypic screening and biological samples were collected and stored in a dedicated biobank.

 

- Autism disorders and intellectual disability

The Centre for Neurogenomics will collaborate with the IRCCS Associazione Oasi Maria Santissima in Troina, Sicily - integrated within the main world consortia - which has recruited over 1500 patients suffering from Autism Spectrum Disorder / Intellectual Disability, on highly sophisticated neurobiology studies aimed at understanding the genetic and epigenetic mechanisms that are activated during brain development, even at the level of a single cell, and at correlating them with phenotyping data obtained through imaging techniques.

 

- Data enhancement from the national healthcare card

The Centre for Computational Biology and the Analysis, Decisions and Society Centre
are working on a highly strategic project whose aim is to access and analyse citizens' health data in the Health Card System, which contains the personal data and medical expenditure data of each individual citizen, from pharmacy purchases to surgeries and doctor visits. The data collected by Health Cards can be used to build predictive models of health status and future events at both individual and population level.