Some rental companies have cars adapted for disabled drivers and / or for transporting people with disabilities.

Hertz
Booking Center: 199 112211
Website: https://www.hertz.com/p/car-rental/italy
Hertz has vehicles with hand controls. The service is available at the Milano Linate and Malpensa agencies. For reservations it is necessary to call at least 72 hours in advance. At the time of rental, you must provide your driving license and a certificate of disability.

Handytechrent
Strada Patro, 3 Moncalvo (AT)
Website: https://www.handytech.it/en/index.html 
This company has multi-adapted cars with automatic transmission, air conditioning and driving aids. 
Rented adapted cars must be collected and returned to: 
Flash Car in via Ragazzi del 99 n. 7, Castellanza (VA). 
Tel. +39 0331 324384 - e-mail: allestimentidisabili@flashcar.it 

Blue Rental
Tel. +39 347 2779881 
email: info@bluerental.it 
Web site: http://www.bluerental.it/4/
Blue Rental rents five-seater cars with automatic transmission adapted to disabled drivers. It also has an adapted car and a six-seater minivan with a place for wheelchair users.